EDIT: A Newer Version of Manga Studio was released December 2012: http://manga.smithmicro.com/mangastudio5/ The new version has many of the same things as the old one, with vast improvements to its coloring functionality (putting it on par with OpenCanvas, SAI, and Painter) and tweaks on the user interface that make it less intimidating for newbies. For illustration, MS5 ("Debut") is best, for comic making, MS5 EX is best. (A hint, wait for sales! They have them all the time on Amazon.com! You can often get MS5 for less than $30 and MS5 EX for under $100!)
The one area MS5 not as good as MS4 is the 3D models. While you can import as before,